In the complex therapy of cerebrovascular accidents, traumatic brain injury and its consequences, encephalopathies of various origins, cognitive impairments (memory and thinking disorders), acute and chronic encephalitis and encephalomyelitis, epilepsy, asthenic conditions (suprasegmental autonomic disorders), reduced learning ability, delays in psychomotor and speech development in children, various forms of cerebral palsy.
Cortexin is contraindicated during pregnancy and lactation.
The drug is administered intramuscularly.
Before injection, the contents of the vial are dissolved in 1-2 ml of a 0.5% solution of procaine (novocaine), water for injection or 0.9% sodium chloride solution (directing the needle to the vial wall to avoid foaming) and administered once daily:
adults at a dose of 10 mg for 10 days;
children with a body weight of up to 20 kg at a dose of 0.5 mg / kg, with a body weight of more than 20 kg at a dose of 10 mg for 10 days.
If necessary, repeat the course after 3-6 months.
With hemispheric ischemic stroke in the acute and early recovery periods for adults at a dose of 10 mg 2 times a day (morning and afternoon) for 10 days, with a second course after 10 days.
CORTEXIN contains a complex of low molecular weight water-soluble polypeptide fractions that penetrate the blood-brain barrier directly to nerve cells. The drug has nootropic, neuroprotective, antioxidant and tissue-specific effects.
Nootropic - improves higher brain functions, learning and memory processes, concentration, stability under various stressful conditions.
Neuroprotective - protects neurons from damage by various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.
Antioxidant - inhibits lipid peroxidation in neurons, increases the survival of neurons under conditions of oxidative stress and hypoxia.
Tissue-specific - activates the metabolism of neurons of the central and peripheral nervous system, reparative processes, improves the functions of the cerebral cortex and the general tone of the nervous system.
The mechanism of action of the drug CORTEKSIN is due to the activation of peptides of neurons and neurotrophic factors of the brain; optimization of the balance of metabolism of excitatory and inhibitory amino acids, dopamine, serotonin; GABAergic effect; a decrease in the level of paroxysmal convulsive activity of the brain, the ability to improve its bioelectrical activity; preventing the formation of free radicals (products of lipid peroxidation).
