Antiviral agent. Specifically suppresses in vitro influenza viruses A and B (Influenzavirus A, B), including highly pathogenic subtypes A (H1N1) pdm09 and A (H5N1), as well as other viruses that cause acute respiratory viral infections (ARVI) (coronavirus (Сoronavirus), associated with severe acute respiratory syndrome (SARS), rhinovirus (Rhinovirus), adenovirus (Adenovirus), respiratory syncytial virus (Pneumovirus) and parainfluenza virus (Paramyxovirus)). According to the mechanism of antiviral action, it belongs to fusion (fusion) inhibitors, interacts with the hemagglutinin of the virus and prevents the fusion of the lipid envelope of the virus and cell membranes. It has a moderate immunomodulatory effect, increases the body's resistance to viral infections. It has interferon-inducing activity - in a study on mice, the induction of interferons was noted already after 16 hours, and high titers of interferons remained in the blood up to 48 hours after administration. Stimulates cellular and humoral immune reactions: increases the number of lymphocytes in the blood, especially T-cells (CD3), increases the number of T-helpers (CD4), without affecting the level of T-suppressors (CD8), normalizes the immunoregulatory index, stimulates the phagocytic function of macrophages and increases the number of natural killer (NK-cells).
Inside, before meals.
Single dose (depending on age):
from 3 to 6 years - 50 mg
from 6 to 12 years - 100 mg
over 12 years old and adults - 200 mg
For children over 3 years of age and adults:
Non-specific prophylaxis during an influenza epidemic and other acute respiratory viral infections in a single dose 2 times a week for 3 weeks.
Non-specific prophylaxis in direct contact with patients with influenza and other acute respiratory viral infections in a single dose 1 time per day for 10-14 days.
Treatment of influenza and other acute respiratory viral infections in a single dose 4 times a day (every 6 hours) for 5 days.
In children from 3 years old:
Complex therapy of acute intestinal infections of rotavirus etiology in a single dose 4 times a day (every 6 hours) for 5 days.
For children over 3 years of age and adults:
Complex therapy of chronic bronchitis, pneumonia, herpes infection in a single dose 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week for 4 weeks.
Prevention of postoperative infectious complications in a single dose 2 days before surgery, then on days 2 and 5 after surgery.
The drug is started from the moment the first symptoms of influenza and other acute respiratory viral infections appear, preferably no later than 3 days from the onset of the disease.
