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Neurovegetative disorders in menopausal syndrome in women with contraindications to hormone replacement therapy (HRT) or refusal to carry it out.
PINEAMIN®, a lyophilisate for solution for intramuscular injection 10 mg, is a complex of water-soluble polypeptide fractions of the pineal gland [pineal gland] of cattle not older than 12 months of age, isolated from the dry extract of Pineamin® (OOO GEROPHARM, Russia), containing glycine as a stabilizer (Ajinomoto Co. Inc., Japan; Panreak, Spain) in a ratio of 1:2.
The drug optimizes the epiphyseal-hypothalamic relationship, normalizes the function of the anterior pituitary gland and the balance of gonadotropic hormones.
In a double-blind, placebo-controlled study of the drug in a population of postmenopausal women, a significant decrease in the severity of menopausal disorders according to the Kupperman index was found due to the positive effect of the drug on the neurovegetative manifestations of menopausal syndrome.
Previously, in preclinical studies on experimental animals, long-term (30 and 90 days) intramuscular administration of PINEAMIN did not reveal any negative effects on the main systems (nervous, cardiovascular, hematopoietic, urinary and respiratory), as well as on metabolism and the general condition of the body.
Contraindications
Hypersensitivity or intolerance to any of the components of the drug, children under 18 years of age, pregnancy and breastfeeding, metrorrhagia (bleeding from the genital tract of unknown origin), hyperestrogenism. Do not use in patients with estrogen-dependent tumors.
Use during pregnancy and during breastfeeding
The drug is not intended for use during pregnancy and during breastfeeding.
The drug is administered intramuscularly.
Before injection, the contents of the vial are dissolved in 1-2 ml of a 0.5% solution of procaine (novocaine), water for injection or 0.9% sodium chloride solution and administered once daily at a dose of 10 mg for 10 days.
If necessary, repeat the course after 3-6 months.
In case of missing an injection, it is not recommended to administer a double dose, but to carry out the next injection as usual on the scheduled day.
PINEAMIN®, a lyophilisate for solution for intramuscular injection 10 mg, is a complex of water-soluble polypeptide fractions of the pineal gland [pineal gland] of cattle not older than 12 months of age, isolated from the dry extract of Pineamin® (OOO GEROPHARM, Russia), containing glycine as a stabilizer (Ajinomoto Co. Inc., Japan; Panreak, Spain) in a ratio of 1:2.
The drug optimizes the epiphyseal-hypothalamic relationship, normalizes the function of the anterior pituitary gland and the balance of gonadotropic hormones.
In a double-blind, placebo-controlled study of the drug in a population of postmenopausal women, a significant decrease in the severity of menopausal disorders according to the Kupperman index was found due to the positive effect of the drug on the neurovegetative manifestations of menopausal syndrome.
Previously, in preclinical studies on experimental animals, long-term (30 and 90 days) intramuscular administration of PINEAMIN did not reveal any negative effects on the main systems (nervous, cardiovascular, hematopoietic, urinary and respiratory), as well as on metabolism and the general condition of the body.
Contraindications
Hypersensitivity or intolerance to any of the components of the drug, children under 18 years of age, pregnancy and breastfeeding, metrorrhagia (bleeding from the genital tract of unknown origin), hyperestrogenism. Do not use in patients with estrogen-dependent tumors.
Use during pregnancy and during breastfeeding
The drug is not intended for use during pregnancy and during breastfeeding.
The drug is administered intramuscularly.
Before injection, the contents of the vial are dissolved in 1-2 ml of a 0.5% solution of procaine (novocaine), water for injection or 0.9% sodium chloride solution and administered once daily at a dose of 10 mg for 10 days.
If necessary, repeat the course after 3-6 months.
In case of missing an injection, it is not recommended to administer a double dose, but to carry out the next injection as usual on the scheduled day.
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