Alpha-melanocyte-stimulating hormone (a-MSH) is also classified as a melanotropin. a-MSH is an endogenous peptide hormone composed of 13 amino acids, believed to play a role in metabolic functions and other biological processes.
Scientists isolated a fragment of this protein hormone and identified its potential biological action, naming it the KPV peptide. KPV is composed of three amino acids: lysine, proline, and valine.
This peptide is the C-terminal fragment of the protein hormone a-MSH, which is believed to be the hormone's core amino acid sequence responsible for its properties.
In 1989, a study was published explaining how the tripeptide was isolated and its biological potential determined.
Having discovered that the terminal COOH peptide in the a-MSH hormone is the primary amino acid signaling sequence, the scientists conducted a preliminary study to determine whether KPV could prevent excessive vascular permeability and excessive blood vessel swelling. For the study, the scientists isolated the KPV peptide and administered it to mice to determine its ability to reduce ear swelling. After completing the study, the scientists reported that the isolated fragment appeared to suppress swelling. KPV's potential anti-inflammatory effects may be due to the inactivation of inflammasomes. It may also suppress the synthesis and release of proinflammatory cytokines in intestinal and immune cells.
Effects:
- KPV reduces inflammation by suppressing proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor (TNF-α). This makes it useful for inflammatory conditions of the skin and body. - The peptide accelerates wound healing and promotes tissue regeneration, improving the restoration of damaged skin and mucous membranes.
- KPV has antimicrobial properties, inhibiting the growth of bacteria such as *Staphylococcus aureus*, making it effective in the treatment of skin infections.
- Using KPV helps reduce redness, irritation, and symptoms associated with conditions such as acne, rosacea, and psoriasis.
- Research suggests that KPV may be beneficial for inflammatory bowel diseases (such as Crohn's disease or ulcerative colitis) by reducing inflammation and strengthening the intestinal mucosa.
- The peptide reduces oxidative stress, protecting cells from damage caused by free radicals.
- KPV helps balance the body's immune response, which may be beneficial for autoimmune diseases or immune hyperreactivity.
100-400 mcg 1-4 sprays per day, 1-3 months
Store in the refrigerator at 2-5°C (37-41°F).
When stored at room temperature, the peptide can remain viable for up to 1 month.
Consult a sports medicine physician before use. Do not use if you are under 21 years of age or if you are pregnant or breastfeeding.