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The drug causes specific lysis of bacteria Staphylococcus, Enterococcus, Streptococcus, enteropathogenic Escherichia coli, Proteus vulgaris, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Klebsiella oxytoca.
Treatment and prevention of purulent-inflammatory and intestinal diseases caused by staphylococci, enterococci, streptococci, Pseudomonas aeruginosa, Klebsiella, pathogenic E. coli of various serogroups, Proteus for internal, rectal and external use:
- diseases of the ear, throat, nose, respiratory tract and lungs - inflammation of the sinuses, middle ear, tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy;
- surgical infections - suppuration of wounds, burns, abscess, phlegmon, boils, carbuncles, hydroadenitis, felons, paraproctitis, mastitis, bursitis, osteomyelitis;
- urogenital infections - urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingo-oophoritis;
- post-traumatic conjunctivitis, keratoconjunctivitis, purulent corneal ulcers and iridocyclitis;
- enteric infections - gastroenterocolitis, cholecystitis, dysbacteriosis;
- generalized septic diseases;
- purulent-inflammatory diseases of newborns - omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc.;
- other diseases caused by bacteria of staphylococci, streptococci, enterococci, Proteus, Klebsiella pneumonia and oxytox, Pseudomonas aeruginosa and Escherichia coli.
For prophylactic purposes, the drug is used to treat surgical and freshly infected wounds, as well as to prevent nosocomial infections according to epidemic indications.
Solution for oral administration, local and external use
COMPOSITION: Sterile purified filtrates of phagolysates of bacteria Staphylococcus, Enterococcus, Streptococcus, enteropathogenic Escherichia coli, Proteus vulgaris, Proteus mirahilis (with Appelman activity - not less than 10-5), Pseudomonas aeruginosa, Klebsiella pneumoniae, Klebsiella oxytoca (with Appelman activity - not less than 10-4) - up to 1 ml.
Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and through the mouth, 7-20 days (according to clinical indications).
The use of bacteriophages does not exclude the use of other antibacterial drugs. If chemical antiseptics were used to treat wounds before using the bacteriophage, the wound should be thoroughly washed with a sterile 0.9% sodium chloride solution.
An important condition for effective phage therapy is the preliminary determination of the sensitivity of the pathogen to the bacteriophage and the early use of the drug.
The drug is not suitable for use in vials with impaired integrity or labeling, if the expiration date has expired, if it becomes cloudy.
Due to the content in the preparation of a nutrient medium in which bacteria from the environment can develop, causing clouding of the preparation, it is necessary to observe the following rules when opening the vial:
- wash your hands thoroughly;
- treat the cap with an alcohol-containing solution; remove the cap without opening the cork;
- do not put the cork with the inner surface on the table or other objects;
- do not leave the vial open;
- Store the opened vial only in the refrigerator.
Before use, the bacteriophage vial must be shaken and viewed. The drug must be transparent.
Opening the vial and extracting the required volume of the drug can be carried out with a sterile syringe by puncturing the stopper. The drug from the opened bottle, subject to the storage conditions, the above rules and the absence of turbidity, can be used during the entire shelf life.
Dosage regimen and method of application
Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and through the mouth, 7-20 days (according to clinical indications).
Depending on the nature of the focus of infection, the bacteriophage is used:
Locally in the form of irrigation, lotions and plugging with liquid phage in an amount of up to 200 ml, depending on the size of the affected area. In abscesses, the bacteriophage is introduced into the cavity of the focus after the removal of pus by puncture. The amount of the injected drug should be slightly less than the volume of the removed pus. In osteomyelitis, after appropriate surgical treatment, a bacteriophage is poured into the wound in 10-20 ml.
Introduction to the cavities - pleural, articular and other limited cavities up to 100 ml of bacteriophage, after which capillary drainage is left, through which the bacteriophage is re-introduced for several days.
With cystitis, pyelonephritis, urethritis, the drug is taken orally. If the cavity of the bladder or renal pelvis is drained, the bacteriophage is administered through a cystostomy or nephrostomy 1-2 times a day, 20-50 ml into the bladder and 5-7 ml into the renal pelvis.
In purulent-inflammatory gynecological diseases, the drug is injected into the cavity of the vagina, uterus at a dose of 5-10 ml once daily.
In purulent-inflammatory diseases of the ear, throat, nose, the drug is administered at a dose of 2-10 ml 1-3 times a day. The bacteriophage is used for rinsing, washing, instillation, the introduction of moistened turundas (leaving them for 1 hour).
With conjunctivitis and keratoconjunctivitis, the drug is instilled 2-3 drops 4-5 times a day, with a purulent corneal ulcer - 4-5 drops, with purulent iridocyclitis, the drug is used 6-8 drops every 3 hours in combination with ingestion.
In the treatment of stomatitis and chronic generalized periodontitis, the drug is used in the form of mouth rinses 3-4 times a day at a dose of 10-20 ml, as well as the introduction of turundas soaked in pyobacteriophage into periodontal pockets for 5-10 minutes.
In intestinal forms of the disease, diseases of internal organs, dysbacteriosis, the bacteriophage is used by mouth and in an enema. Bacteriophage is given through the mouth 3 times a day on an empty stomach 1 hour before meals. In the form of enemas, it is prescribed 1 time per day instead of one dose by mouth.
The use of bacteriophages does not exclude the use of other antibacterial drugs.
If chemical antiseptics were used to treat wounds before using the bacteriophage, the wound should be thoroughly washed with a sterile 0.9% sodium chloride solution.
The use of bacteriophage in children (up to 6 months).
With sepsis, enterocolitis of newborns, including premature babies, bacteriophage is used in the form of high enemas (through a gas outlet tube or catheter) 2-3 times a day (see table).
In the absence of vomiting and regurgitation, it is possible to use the drug through the mouth. In this case, it is mixed with breast milk.
Perhaps a combination of rectal (in enemas) and oral (through the mouth) use of the drug. The course of treatment is 5-15 days.
With a recurrent course of the disease, repeated courses of treatment are possible.
In order to prevent sepsis and enterocolitis in case of intrauterine infection or the risk of nosocomial infection in newborns, the bacteriophage is used in the form of enemas 2 times a day for 5-7 days.
In the treatment of omphalitis, pyoderma, infected wounds, the drug is used in the form of applications twice daily (a gauze cloth is moistened with a bacteriophage and applied to the umbilical wound or to the affected area of the skin).
Treatment and prevention of purulent-inflammatory and intestinal diseases caused by staphylococci, enterococci, streptococci, Pseudomonas aeruginosa, Klebsiella, pathogenic E. coli of various serogroups, Proteus for internal, rectal and external use:
- diseases of the ear, throat, nose, respiratory tract and lungs - inflammation of the sinuses, middle ear, tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy;
- surgical infections - suppuration of wounds, burns, abscess, phlegmon, boils, carbuncles, hydroadenitis, felons, paraproctitis, mastitis, bursitis, osteomyelitis;
- urogenital infections - urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingo-oophoritis;
- post-traumatic conjunctivitis, keratoconjunctivitis, purulent corneal ulcers and iridocyclitis;
- enteric infections - gastroenterocolitis, cholecystitis, dysbacteriosis;
- generalized septic diseases;
- purulent-inflammatory diseases of newborns - omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc.;
- other diseases caused by bacteria of staphylococci, streptococci, enterococci, Proteus, Klebsiella pneumonia and oxytox, Pseudomonas aeruginosa and Escherichia coli.
For prophylactic purposes, the drug is used to treat surgical and freshly infected wounds, as well as to prevent nosocomial infections according to epidemic indications.
Solution for oral administration, local and external use
COMPOSITION: Sterile purified filtrates of phagolysates of bacteria Staphylococcus, Enterococcus, Streptococcus, enteropathogenic Escherichia coli, Proteus vulgaris, Proteus mirahilis (with Appelman activity - not less than 10-5), Pseudomonas aeruginosa, Klebsiella pneumoniae, Klebsiella oxytoca (with Appelman activity - not less than 10-4) - up to 1 ml.
Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and through the mouth, 7-20 days (according to clinical indications).
The use of bacteriophages does not exclude the use of other antibacterial drugs. If chemical antiseptics were used to treat wounds before using the bacteriophage, the wound should be thoroughly washed with a sterile 0.9% sodium chloride solution.
An important condition for effective phage therapy is the preliminary determination of the sensitivity of the pathogen to the bacteriophage and the early use of the drug.
The drug is not suitable for use in vials with impaired integrity or labeling, if the expiration date has expired, if it becomes cloudy.
Due to the content in the preparation of a nutrient medium in which bacteria from the environment can develop, causing clouding of the preparation, it is necessary to observe the following rules when opening the vial:
- wash your hands thoroughly;
- treat the cap with an alcohol-containing solution; remove the cap without opening the cork;
- do not put the cork with the inner surface on the table or other objects;
- do not leave the vial open;
- Store the opened vial only in the refrigerator.
Before use, the bacteriophage vial must be shaken and viewed. The drug must be transparent.
Opening the vial and extracting the required volume of the drug can be carried out with a sterile syringe by puncturing the stopper. The drug from the opened bottle, subject to the storage conditions, the above rules and the absence of turbidity, can be used during the entire shelf life.
Dosage regimen and method of application
Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and through the mouth, 7-20 days (according to clinical indications).
Depending on the nature of the focus of infection, the bacteriophage is used:
Locally in the form of irrigation, lotions and plugging with liquid phage in an amount of up to 200 ml, depending on the size of the affected area. In abscesses, the bacteriophage is introduced into the cavity of the focus after the removal of pus by puncture. The amount of the injected drug should be slightly less than the volume of the removed pus. In osteomyelitis, after appropriate surgical treatment, a bacteriophage is poured into the wound in 10-20 ml.
Introduction to the cavities - pleural, articular and other limited cavities up to 100 ml of bacteriophage, after which capillary drainage is left, through which the bacteriophage is re-introduced for several days.
With cystitis, pyelonephritis, urethritis, the drug is taken orally. If the cavity of the bladder or renal pelvis is drained, the bacteriophage is administered through a cystostomy or nephrostomy 1-2 times a day, 20-50 ml into the bladder and 5-7 ml into the renal pelvis.
In purulent-inflammatory gynecological diseases, the drug is injected into the cavity of the vagina, uterus at a dose of 5-10 ml once daily.
In purulent-inflammatory diseases of the ear, throat, nose, the drug is administered at a dose of 2-10 ml 1-3 times a day. The bacteriophage is used for rinsing, washing, instillation, the introduction of moistened turundas (leaving them for 1 hour).
With conjunctivitis and keratoconjunctivitis, the drug is instilled 2-3 drops 4-5 times a day, with a purulent corneal ulcer - 4-5 drops, with purulent iridocyclitis, the drug is used 6-8 drops every 3 hours in combination with ingestion.
In the treatment of stomatitis and chronic generalized periodontitis, the drug is used in the form of mouth rinses 3-4 times a day at a dose of 10-20 ml, as well as the introduction of turundas soaked in pyobacteriophage into periodontal pockets for 5-10 minutes.
In intestinal forms of the disease, diseases of internal organs, dysbacteriosis, the bacteriophage is used by mouth and in an enema. Bacteriophage is given through the mouth 3 times a day on an empty stomach 1 hour before meals. In the form of enemas, it is prescribed 1 time per day instead of one dose by mouth.
The use of bacteriophages does not exclude the use of other antibacterial drugs.
If chemical antiseptics were used to treat wounds before using the bacteriophage, the wound should be thoroughly washed with a sterile 0.9% sodium chloride solution.
The use of bacteriophage in children (up to 6 months).
With sepsis, enterocolitis of newborns, including premature babies, bacteriophage is used in the form of high enemas (through a gas outlet tube or catheter) 2-3 times a day (see table).
In the absence of vomiting and regurgitation, it is possible to use the drug through the mouth. In this case, it is mixed with breast milk.
Perhaps a combination of rectal (in enemas) and oral (through the mouth) use of the drug. The course of treatment is 5-15 days.
With a recurrent course of the disease, repeated courses of treatment are possible.
In order to prevent sepsis and enterocolitis in case of intrauterine infection or the risk of nosocomial infection in newborns, the bacteriophage is used in the form of enemas 2 times a day for 5-7 days.
In the treatment of omphalitis, pyoderma, infected wounds, the drug is used in the form of applications twice daily (a gauze cloth is moistened with a bacteriophage and applied to the umbilical wound or to the affected area of the skin).
| AGE OF THE PATIENT | Dose of the drug (ml) | |
|---|---|---|
| ORAL | RECTAL | |
| 0 – 6 months | 5 | 10 |
| 6 – 12 months | 10 | 20 |
| 1-3 years | 15 | 30 |
| 3-8 years | 20 | 40 |
| 8 years and older | 30 | 50 |
4605021003281
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